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FACTOR XII
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DeCS
Descriptor
English
:
Factor XII
Descriptor
Spanish
:
Factor XII
Descriptor
Portuguese
:
Fator XII
Synonyms
English
:
Hageman Factor
Coagulation Factor XII
Tree Number:
D12.776.124.125.450
D23.119.450
Definition
English
:
Stable
blood coagulation
factor activated by contact with the subendothelial surface of an injured vessel. Along with
prekallikrein
, it serves as the contact factor that initiates the intrinsic pathway of
blood coagulation
. Kallikrein activates
factor XII
to XIIa. Deficiency of
factor XII
, also called the Hageman trait, leads to increased
incidence
of thromboembolic
disease.
Indexing Annotation
English
:
a
blood
coag factor
Entry Combination - descr/qualif
English
:
Factor XII
/
deficiency
use
Factor XII Deficiency
See Related
English
:
Coagulants
History Note
English
:
66(64)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22175
Unique Identifier:
D005174
Occurrence in VHL
:
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